1.

Sheila could not sleep although she was really tired.

DESPITE

Sheila could not sleep DESPITE BEING really tired.

2.

 Although Mark was tired, he went to the office.

BUT

Mark was tired, BUT he went to the office.

3.

Father managed to cook in spite of his injured hand.

ALTHOUGH

Father managed to cook ALTHOUGH HIS HAND WAS INJURED.

4.

Pablo decided to accept the job although the salary was very low.

IN SPITE OF

Pablo decided to accept the job IN SPITE OF THE VERY LOW SALARY.

Pablo decided to accept the job IN SPITE OF THE SALARY BEING LOW.

5.

In spite of my injured knee, I managed to walk to the hospital.

ALTHOUGH

ALTHOUGH I HAD INJURED MY KNEE, I managed to walk to the hospital.

ALTHOUGH MY KNEE WAS INJURED, I managed to walk to the hospital.