1.

Would you be uncomfortable with leaving your family?

One thing    is leaving my family.

2.

Would you feel comfortable about traveling alone?

Something    is traveling alone.

3.

Would you be enthusiastic about making new friends?

The one thing    is making new friends.

4.

Would you be curious about the way people live in Africa?

The thing    is the way people live in Africa.

5.

Would you be anxious about spending too much money?

The only thing    is spending too much money.